Fig. 2: Highly sensitive and specific SARS-CoV-2 antibody test. | Nature Biomedical Engineering

Fig. 2: Highly sensitive and specific SARS-CoV-2 antibody test.

From: Quantification of antibody avidities and accurate detection of SARS-CoV-2 antibodies in serum and saliva on plasmonic substrates

Fig. 2: Highly sensitive and specific SARS-CoV-2 antibody test.

a, Percentage of samples with IgM/IgG antibody status combinations according to days from symptom onset to sample collection date in the ranges 0–7, 8–14 and 15–45 days. Data based on 'sample set 2' are from patients with COVID-19, collected on specific days post symptom onset. b, Box plots of IgG levels detected in four sets of serum samples against the S1 antigen with a cutoff value of 1.62 displayed as a red dashed line. Inset: a close-up of normalized IgG levels by sample set near the cutoff with one false positive. ‘PCR+’ denotes serum samples from patients who tested positive by PCR for COVID-19 (n = 136) and ‘PCR−’ denotes those who tested negative (n = 33). ‘Pre-pand.’ corresponds to pre-pandemic collected samples (n = 351). ‘Cross R.’ corresponds to samples from patients with other diseases for cross-reactivity evaluation (n = 73). c, The same as b, except for IgM levels, with a cutoff value of 1.38. Inset: a close-up of normalized IgM levels by sample set near the cutoff, with one false positive. Data in b and c are presented as box plots with the minima, maxima, median line, interquartile range, data points and outliers shown.

Back to article page