Extended Data Fig. 5: Anti-infective activity of encrypted peptides in a neutropenic thigh infection mouse model. | Nature Biomedical Engineering

Extended Data Fig. 5: Anti-infective activity of encrypted peptides in a neutropenic thigh infection mouse model.

From: Mining for encrypted peptide antibiotics in the human proteome

Extended Data Fig. 5

Treatment with 4-fold MIC of SCUB1-SKE25 (100 μmol L-1; 311.6 μg mL-1) and SCUB3-MLP22 (100 μmol L-1; 267.6 μg mL-1) alone and in combination (at 12.5 and 25 μmol L-1, respectively). Both monotherapy and combination therapy displayed similar antimicrobial activity against A. baumannii ATCC19606 to treatment groups using the MIC of each peptide. Polymyxin B and levofloxacin were used as controls, the former of which completely cleared the infection. The statistical significance was determined using one-way ANOVA, ****p < 0.0001, features on the violin plots represent median and upper and lower quartiles. Four mice were used per group.

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