Extended Data Fig. 2: Validation of antitumour activity of the three drug candidates in human tumour organoids. | Nature Biomedical Engineering

Extended Data Fig. 2: Validation of antitumour activity of the three drug candidates in human tumour organoids.

From: An organoid-based screen for epigenetic inhibitors that stimulate antigen presentation and potentiate T-cell-mediated cytotoxicity

Extended Data Fig. 2: Validation of antitumour activity of the three drug candidates in human tumour organoids.

a, Schematic illustration of the drug-validation test using NY-ESO-1+ MDA-MB-468 organoids co-cultured with NY-ESO-1-specific CD8+ T cells. Human breast cancer-associated fibroblasts (CAFs) were used with MDA-MB-468 cells to generate tumour organoids. b, Optical images showing the co-culture of the CD8+ T cells and MDA-MB-468 tumour organoids treated with control or drug candidates.

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