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MECHANOPATHOLOGY

Less fibrosis around softer silicone implants

Nature Biomedical Engineering volume 5, pages 1407–1408 (2021)Cite this article

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Softening the surface of silicone implants reduces their fibrotic encapsulation.

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Fig. 1: Mitigation of the fibrotic encapsulation of silicone implants via soft coatings or through the inhibition of the binding of specific integrins.

References

  1. Gong, T., Liu, L., Jiang, W. & Zhou, R. Nat. Rev. Immunol. 20, 95–112 (2020).

    Article  CAS  Google Scholar 

  2. Franz, S., Rammelt, S., Scharnweber, D. & Simon, J. C. Biomaterials 32, 6692–6709 (2011).

    Article  CAS  Google Scholar 

  3. Mariani, E., Lisignoli, G., Borzì, R. M. & Pulsatelli, L. Int. J. Mol. Sci. 20, 636 (2019).

    Article  CAS  Google Scholar 

  4. Doloff, J. C. et al. Nat. Mater. 16, 671–680 (2017).

    Article  CAS  Google Scholar 

  5. Farah, S. et al. Nat. Mater. 18, 892–904 (2019).

    Article  CAS  Google Scholar 

  6. Major, M. R., Wong, V. W., Nelson, E. R., Longaker, M. T. & Gurtner, G. C. Plast. Reconstr. Surg. 135, 1489–1498 (2015).

    Article  CAS  Google Scholar 

  7. Luvsannyam, E. et al. Cureus 12, e10341 (2020).

    PubMed  PubMed Central  Google Scholar 

  8. Noskovicova, N. et al. Nat. Biomed. Eng. 5, https://doi.org/10.1038/s41551-021-00722-z (2021).

  9. Meng, X.-M., Nikolic-Paterson, D. J. & Lan, H. Y. Nat. Rev. Nephrol. 12, 325–338 (2016).

    Article  CAS  Google Scholar 

  10. Buxboim, A., Ivanovska, I. L. & Discher, D. E. J. Cell Sci. 123, 297–308 (2010).

    Article  CAS  Google Scholar 

  11. Gieseck, R. L. III, Wilson, M. S. & Wynn, T. A. Nat. Rev. Immunol. 18, 62–76 (2018).

    Article  CAS  Google Scholar 

  12. Corradetti, B. (ed) The Immune Response to Implanted Materials and Devices (Springer, Cham, 2017).

  13. Desai, T. & Shea, L. D. Nat. Rev. Drug Discov. 16, 338–350 (2017).

    Article  CAS  Google Scholar 

  14. Doloff, J. C. et al. Nat. Biomed. Eng. 5, 1115–1130 (2021).

    Article  CAS  Google Scholar 

  15. Aamodt, J. M. & Grainger, D. W. Biomaterials 86, 68–82 (2016).

    Article  CAS  Google Scholar 

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Authors and Affiliations

  1. Department of Biomedical Engineering, Translational Tissue Engineering Center, Wilmer Eye Institute, Johns Hopkins University School of Medicine, Baltimore, MD, USA

    Stuart J. Bauer & Joshua C. Doloff

  2. Department of Materials Science and Engineering, Institute of NanoBioTechnology, Johns Hopkins University, Baltimore, MD, USA

    Joshua C. Doloff

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  1. Stuart J. Bauer
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  2. Joshua C. Doloff
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Correspondence to Joshua C. Doloff.

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Bauer, S.J., Doloff, J.C. Less fibrosis around softer silicone implants. Nat Biomed Eng 5, 1407–1408 (2021). https://doi.org/10.1038/s41551-021-00830-w

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