Extended Data Fig. 1: Hepatic pFUS attenuates hyperglycemia in mice.
a. Hepatic pFUS attenuates hyperglycemia in western diet-fed mice. Blood glucose levels were measured at week 9 (white plots), prior to the stimulation period and week 16 (grey plots), post-stimulation period. Daily stimulated western diet-fed mice had significantly reduced blood glucose levels across the stimulation period (WD–pFUS, week 9 vs week 16; p-values shown are derived using nonparametric Wilcoxon rank-sum test and corrected using the Bonferroni method (n = 14 per group; Box plot presents the data median, first and third quartiles and the whiskers are the 1.5 x range (IQR). If no points exceed 1.5 x IQR distance, then the whiskers are simply the minimum and maximum values). b. Hepatic pFUS attenuates hyperinsulinemia in western diet-fed mice. Insulin levels were measured at week 9 (white plots), prior to the stimulation period, and at week 16 (grey plots), post-stimulation period. WD–pFUS mice had significantly reduced insulin levels across the stimulation period (WD–pFUS, week 9 vs week 16, p-values shown are derived using nonparametric Wilcoxon rank-sum test (two-sided) and corrected using the Bonferroni method (n = 10 per group; Box plot presents the data quartiles and whiskers are the minimum and maximum values unless value exceeds the 1.5 x IQR distance).
