Extended Data Fig. 3: Kinesin-2 knockout tumors exhibit differentiation defects. | Nature Biomedical Engineering

Extended Data Fig. 3: Kinesin-2 knockout tumors exhibit differentiation defects.

From: Modelling ciliopathy phenotypes in human tissues derived from pluripotent stem cells with genetically ablated cilia

Extended Data Fig. 3

a, Representative photographs of whole, unfixed growths retrieved from immunodeficient animals at the same time point. Growths are sliced through their centers to reveal the internal surface. b, A second set of tumors, photographed intact after retrieval from the animals. c-e, Quantification of tissue subtypes within teratomas as a fraction of total area (mean ± s.e.m., n ≥ 5 independent biological replicates per condition from a total of 14 distinct cell lines). f, Ratio of area occupied by SOX2+ cells in TUJ1+ patches of teratoma sections (mean ± s.e.m., n ≥ 4 independent biological replicates per condition from a total of 6 distinct cell lines; *, p = 0.0391).

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