Extended Data Fig. 4: PGNPs-Amp effectively eliminate Listeria monocytogenes in a bacteremia model.
a, Study design: mice were received an intravenous injection with 2 × 106 CFUs of Listeria monocytogenes. Free Amp (40 mg kg−1) or Amp (40 mg kg−1)-loaded PGNPs was orally administered into mice. Control mice did not receive antibiotic treatment. Bacterial loads in blood, liver, spleen were determined at 24 h post infection. b, The appearance of the infected liver and spleen in mice with indicated treatments at 24 h post infection. c–e, Quantification of bacteria CFUs in the blood (c), liver (d), and spleen (e) at 24 h post infection. n = 6 mice. All values are expressed as mean ± s.e.m. Statistical significance was determined using one-way ANOVA with Tukey’s multiple comparisons test in (c, d and e). *P < 0.05, **P < 0.01, ***P < 0.001, ****P < 0.0001. b–e are representative of two independent experiments.
