Extended Data Fig. 8: Comparison of CD8αβ TRAC-1XX-iT cells and peripheral blood lymphocytes. | Nature Biomedical Engineering

Extended Data Fig. 8: Comparison of CD8αβ TRAC-1XX-iT cells and peripheral blood lymphocytes.

From: Generation of T-cell-receptor-negative CD8αβ-positive CAR T cells from T-cell-derived induced pluripotent stem cells

Extended Data Fig. 8

a, Representative examples of lymphoid phenotype marker expression in CD8αβ TRAC-1XX-iT (CD8αβ iT, red), CD8αβ αβTCR-T (CD8, blue), CD4 αβTCR-T (CD4, orange), γδTCR-T (γδ, green) and NK cells (NK, purple). CD8αβ TRAC-1XX-iT cells are the same as represented in Fig. 5a. b, Variability of lymphoid phenotype marker expression in CD8αβ TRAC-1XX-iT cells (n = 3-4 biological replicates, data are means ± s.d). Biological replicates shown are samples utilized in RNA analysis (Fig. 5b,c). c, Principal Component Analysis comparing TRAC-1XX CD8αβ αβTCR-T cells (CD8, n = 4), TRAC-1XX CD4 αβTCR-T cells (CD4, n = 3), γRV-1XX γδTCR-T cells (γδ, n = 4), γRV-1XX NK cells (NK, n = 4) and CD8αβ+ TRAC-1XX-iT cells (iT CD8αβ, n = 4).

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