Fig. 3: Schematic and representative raw cyclic voltammetry data of the multiplexed serology assay. | Nature Biomedical Engineering

Fig. 3: Schematic and representative raw cyclic voltammetry data of the multiplexed serology assay.

From: A lab-on-a-chip for the concurrent electrochemical detection of SARS-CoV-2 RNA and anti-SARS-CoV-2 antibodies in saliva and plasma

Fig. 3

a, Schematic illustrating the multiplexed EC serological assay to assess host antibody responses on electrodes functionalized with SARS-CoV-2 antigens. Host antibodies bind to the SARS-CoV-2 antigens immobilized on the chips. Subsequently, biotinylated anti-human IgG secondary antibodies bind, followed by polystreptavidin-HRP binding and TMB precipitation on the chips. b–e, Typical cyclic voltammograms for the four different electrodes that target host antibodies against S1 subunit (b), S1-RBD (c), N (d), and BSA negative control (e). f, ROC curves generated from the patient sample data obtained for the IgG EC serology assay.

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