Table 1 ROC curve analysis for electrochemical assays

From: A lab-on-a-chip for the concurrent electrochemical detection of SARS-CoV-2 RNA and anti-SARS-CoV-2 antibodies in saliva and plasma

 

Viral RNA

Serology (IgG)

Electrode

ORF1a RNA

S1

S1-RBD

N

Combined

Area under the curve

1.00

0.98

1.00

0.98

1.00

95% CI

(1.00, 1.00)

(0.95, 1.00)

(1.00, 1.00)

(0.95, 1.00)

(1.00, 1.00)

P value

<0.0001

<0.0001

<0.0001

<0.0001

<0.0001

Cut-off

8,859

>1.9 × 10–7

>1.7 × 10–7

>3.1 × 10–8

>2.4 × 10–7

Sensitivity, 95% CI

1.00, (0.83, 1.00)

0.95, (0.83, 0.97)

1.00, (0.94, 1.00)

0.95, (0.86, 0.98)

1.00, (0.94, 1.00)

Specificity, 95% CI

1.00, (0.74, 1.00)

1.00, (0.93, 1.00)

1.00, (0.93, 1.00)

1.00, (0.93, 1.00)

1.00, (0.93, 1.00)

Number of positive samples

19

54

54

54

54

Number of negative samples

11

58

58

58

58

  1. Summary of the numerical values of the ROC curve analysis of the patient sample data collected for the SARS-CoV-2 biomarker assays for detection of (left to right) ORF1a RNA, S1 subunit, S1-RBD, N and a combined assay. Positive and negative SARS-CoV-2 samples were confirmed by RT–qPCR. CI, confidence interval.
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