Fig. 3: Human IgG transgenic minipigs mount normal antibody responses towards the T-cell dependent antigen KLH.
From: A humanized minipig model for the toxicological testing of therapeutic recombinant antibodies
a, Human IgG transgenic minipigs (n = 2) mount porcine IgG anti-KLH antibody responses at comparable levels to that of WT animals (n = 2) upon single immunization with KLH in alum adjuvant. b, Human IgG transgenic minipigs (n = 2) can mount memory responses after rechallenge with KLH at day 35 (arrow). The dotted red line indicates an arbitrary threshold at a titre of 200. Statistical analysis by 2-way analysis of variance (ANOVA); NS, not significant. Horizontal bar represents median. Each data point represents a biological replicate.
