Fig. 5: Human IgG transgenic minipigs mount ADA responses against human IgG1 antibodies with increased clinical immunogenicity. | Nature Biomedical Engineering

Fig. 5: Human IgG transgenic minipigs mount ADA responses against human IgG1 antibodies with increased clinical immunogenicity.

From: A humanized minipig model for the toxicological testing of therapeutic recombinant antibodies

Fig. 5: Human IgG transgenic minipigs mount ADA responses against human IgG1 antibodies with increased clinical immunogenicity.The alternative text for this image may have been generated using AI.

a, Porcine IgG anti-cergutuzumab amunaleukin antibodies after immunization (TG minipigs, n = 4; WT minipigs, n = 4) with cergutuzumab amunaleukin. b, Porcine IgG anti-atezolizumab antibodies after immunization with atezolizumab. The dotted red line indicates an arbitrary threshold at a titre of 200. Statistical analysis by 2-way ANOVA. Horizontal bar represents median. Each data point represents a biological replicate.

Source data

Back to article page