Extended Data Fig. 3: Changes of AQP4, kio and other characters upon TMZ treatment on C6 cell line. | Nature Biomedical Engineering

Extended Data Fig. 3: Changes of AQP4, kio and other characters upon TMZ treatment on C6 cell line.

From: Transmembrane water-efflux rate measured by magnetic resonance imaging as a biomarker of the expression of aquaporin-4 in gliomas

Extended Data Fig. 3

a-f: The changes in a, kio, n = (4, 6, 4, 6), p = 0.0099, p = 0.0006. b, AQP4 (rfu) / DAPI (rfu), n = (2, 5, 3, 3), p = 0.0328, p < 0.0001 c, migration length (normalized by the control groups), n = (5, 4, 8, 8), p = 0.0836, p = 0.0001, d, Ki-67 (rfu) / DAPI (rfu), n = (3, 6, 3, 6), p = 0.1041, p = 0.0133 e, cell proliferation speed, n = (6, 15, 3, 34, 13), p = 0.0505, p = 0.0001, and f, the SCCs fraction (OG+ cells/ total cells), n = (4, 3, 3, 3), p < 0.0001. Here, control group represents C6 cell lines incubated with DMSO only. In e, the results from AQP4 KO group is also shown. The data is shown as mean ± SEM. * p < 0.05, ** p < 0.01, *** p < 0.001, **** p < 0.0001, ns, Non-significant, From a to f, two-sided unpaired t-test between 3days and 7days in control, p = (0.3612, 0.7030, 0.9999, 0.3611, 0.7981, 0.1001). Here, the data points overlay the corresponding box.

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