Extended Data Fig. 7: A linear correlation is observed between kio and AQP4 expression in the rat orthotopic model of C6 glioma. | Nature Biomedical Engineering

Extended Data Fig. 7: A linear correlation is observed between kio and AQP4 expression in the rat orthotopic model of C6 glioma.

From: Transmembrane water-efflux rate measured by magnetic resonance imaging as a biomarker of the expression of aquaporin-4 in gliomas

Extended Data Fig. 7

a, b: Typical examples of kio maps and AQP4 IHC results from two animals with small (a) and large kio (b) values. From up to down, they are the contrast-enhanced T1-weighted images (the position of tumor was illustrated with the white dashed circle), the kio maps overlaid on the T1-weighted images, and the typical AQP4 IHC results of the position pointed by the white arrows. MRI Scale bar, 2 mm; IHC Scale bar, 25 µm. c: A linear correlation is observed between the whole-tumor-averaged kio and of AQP4+ fractions in the seven rats of orthotopic glioma. The solid line reflects linear regression analysis and the two dashed curves denote 95% confidence intervals. n = 7.

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