Fig. 2: Chemical composition and structural characterization of butyrate-prodrug micelles NtL-ButM and Neg-ButM. | Nature Biomedical Engineering

Fig. 2: Chemical composition and structural characterization of butyrate-prodrug micelles NtL-ButM and Neg-ButM.

From: Treatment of peanut allergy and colitis in mice via the intestinal release of butyrate from polymeric micelles

Fig. 2

NtL-ButM consists of the neutral block copolymer pHPMA-b-pBMA and Neg-ButM consists of the anionic block copolymer pMAA-b-pBMA. a, Synthetic route of pHPMA-b-pBMA and pMAA-b-pBMA, and fabrication of polymeric micelles. Top: NtL-ButM contains a hydrophilic (HPMA) block as the micelle corona, while a hydrophobic (BMA) block forms the micelle core. Bottom: Neg-ButM contains a hydrophilic (MAA) block that forms a negatively charged micelle corona, and the same hydrophobic (BMA) block as NtL-ButM. b,c, CryoEM images show the spherical structures of micelles NtL-ButM (b) or Neg-ButM (c). d, Table summarizing the characterization of micelles NtL-ButM and Neg-ButM, including hydrodynamic diameter and z-potential from DLS, critical micelle concentration, radius of gyration and aggregation number from SAXS.

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