Extended Data Fig. 5: Evaluation of long term COL1A1-EV MN dermal wrinkle treatment by skin replica plaster. | Nature Biomedical Engineering

Extended Data Fig. 5: Evaluation of long term COL1A1-EV MN dermal wrinkle treatment by skin replica plaster.

From: Intradermally delivered mRNA-encapsulating extracellular vesicles for collagen-replacement therapy

Extended Data Fig. 5: Evaluation of long term COL1A1-EV MN dermal wrinkle treatment by skin replica plaster.The alt text for this image may have been generated using AI.

a–c, Microscopic observation of dorsal skin and skin replica at 1 month, 2 months, and 3 months after treatment. Scale bar, 5 mm. d, e Quantification of mean wrinkle length (n = 4 for all groups, ***P < 0.001 COL1A1-EV MN vs Saline at 1 month and 2 months; ###P < 0.001 Needle injection vs Saline at 1 month; ††P = 0.031 HA MN vs Saline at 1 month;※※P = 0.029 Unloaded EV MN vs Saline at 1 month) and mean wrinkle depth (n = 4 for all groups, ***P < 0.001 COL1A1-EV MN vs Saline at 1 month; **P = 0.001 COL1A1-EV MN vs Saline at 2 months; Needle injection vs Saline not significant at 1 month; HA MN vs Saline not significant at 1 month) from skin replicas. All data are from three independent experiments and are presented as means ± SEM. Two-way ANOVA was used for the comparisons in (d, e).

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