Extended Data Fig. 5: CLIP enables Cas13d stabilization in primary T cells.
From: Stable expression of large transgenes via the knock-in of an integrase-deficient lentivirus
a, Magnitude of expression at Day 7 when GFP was knocked into IL2RG or ACTB in primary T cells (****: p < 0.0001). Histogram data shown in Figs. 4c,d and supplemental Fig. 6. b, Stability of mCherry-P2A-Cas13d in primary T cells compared between CLIP in the ACTB locus and randomly integrating lentiviruses driven by an EF1α or SFFV promoter (error bars represent SEM).
