Extended Data Fig. 5: IL6S ablates the accumulation of multiple cytokines in the mouse brain. | Nature Biomedical Engineering

Extended Data Fig. 5: IL6S ablates the accumulation of multiple cytokines in the mouse brain.

From: Suppression of cytokine release syndrome during CAR-T-cell therapy via a subcutaneously injected interleukin-6-adsorbing hydrogel

Extended Data Fig. 5: IL6S ablates the accumulation of multiple cytokines in the mouse brain.

a, Schematic showing the process of CRS model construction and the treatment with free antibodies or IL6S. 2 days post-injection of CAR-T cells, brain tissue of mice was collected for multi-cytokine measurements. The concentrations of murine IL-6 (b), CCL2 (c), SAA3 (d), G-CSF (e) and CXCL9 (f), human GM-CSF (g) and IL-3 (h) in brain tissue. Data are presented as mean ± s.d. (n = 5). Two-sided Welch’s t-test was used for the calculation of the statistical differences in (b), (d), (e) and (g). There is no significant (ns) difference between groups when the P value is higher than 0.05. nsP > 0.05, *P < 0.05, **P < 0.01, ***P < 0.001.

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