Extended Data Fig. 10: Lasso model construction strategy and comparative summary of different types of Cas13 RNA targeting. | Nature Biomedical Engineering

Extended Data Fig. 10: Lasso model construction strategy and comparative summary of different types of Cas13 RNA targeting.

From: Intrinsic targeting of host RNA by Cas13 constrains its utility

Extended Data Fig. 10: Lasso model construction strategy and comparative summary of different types of Cas13 RNA targeting.The alternative text for this image may have been generated using AI.

a, Early loss of crRNAs targeting non-essential genes in one-vector or two-vector Cas13d screens. Log2 fold-change (Day 5 vs. plasmid pool) < −0.5. b, Schematic of lasso-based machine learning model to determine crRNA-specific features underlying lentiviral defect. c, Comparison of features between different types of Cas13 activities.

Source data

Back to article page