Extended Data Fig. 4: Effect of vascularization on oxygenation outcomes. | Nature Biomedical Engineering

Extended Data Fig. 4: Effect of vascularization on oxygenation outcomes.

From: Inflammation-induced subcutaneous neovascularization for the long-term survival of encapsulated islets without immunosuppression

Extended Data Fig. 4: Effect of vascularization on oxygenation outcomes.The alternative text for this image may have been generated using AI.

a, Distribution of EPR oxygen measurements in the unmodified and vascularized sites (this figure is a copy of Fig. 2m); mean ± SD. b, Probability density functions of the best-fit normal distributions to the absolute pO2 measurements at the unmodified and vascularized sites shown in a. c–f, Results from Monte Carlo simulations of the rat islet device where the external boundary pO2, pext, was treated as a random variable described by the normal distributions shown in b. Mean pO2 (c and d) and net necrotic fraction within rat islets (e and f) in devices in the unmodified and vascularized sites. Data was compared in bar graphs (c and e) and in relation to the simulated value of pext (d and f). c and e: ****p < 0.0001 (two-sided Mann-Whitney U test); mean ± SD.

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