Extended Data Fig. 1: Assessment of inflammatory responses promoting neovascularization.
a, Schematic representation of the experimental design to evaluate the localized inflammatory response at the unmodified (control) and vascularized site. Three time points were evaluated: 1) 1-week post-catheter implantation in the vascularized site (n = 9), 2) At implantation of the device in the vascularized site (i.e., 4-6 weeks post-catheter implantation) (n = 5), and 3) 3 days post-device implantation at both the vascularized and unmodified/non-prevascularized site (n = 4). b−f, Inflammatory assays showing tissue cytokine levels at the unmodified and modified subcutaneous site; data points represent medians and interquartile ranges. Groups are compared using Mann-Whitney U tests for independent samples and Wilcoxon matched-pairs signed rank tests, as appropriate; Data are shown as median with interquartile range.
