Table 1 Description of the 7 features that change monotonically (decrease/increase) with diabetes stage/progression and P values of changes
Feature number | Feature description | Feature scale | Feature change | P values | ||
|---|---|---|---|---|---|---|
A vs B | B vs C | A vs C | ||||
3 | Number of junction-to-junction branches in the dermal layer (2D) | Mesoscale | ↓ | 0.047* | 0.153 | 0.01** |
5 | Thickness of the dermal layer (3D) | Macroscale | ↓ | 0.464 | 0.188 | 0.252 |
6 | Total area of vessels in the dermal layer (3D) | Macroscale | ↓ | 0.317 | 0.326 | 0.477 |
8 | Average vessel length in the dermal layer (2D) | Microscale | ↓ | 0.156 | 0.336 | 0.315 |
13 | Number of vessels in the dermal layer (3D) | Mesoscale | ↓ | 0.395 | 0.364 | 0.276 |
20 | Number of junctions in the dermal layer (3D) | Mesoscale | ↓ | 0.387 | 0.373 | 0.276 |
21 | Number of junction-to-junction branches in the dermal layer (3D) | Mesoscale | ↓ | 0.349 | 0.221 | 0.331 |
1 | Number of vessels in the epidermal/SVP layer (2D) | Mesoscale | ↑ | 0.257 | 0.386 | 0.323 |
2 | Number of junctions in the epidermal/SVP layer (2D) | Mesoscale | ↑ | 0.263 | 0.444 | 0.377 |
4 | Number of junction-to-junction branches in the epidermal/SVP layer (2D) | Mesoscale | ↑ | 0.447 | 0.266 | 0.377 |
25 | Average vessel area in the epidermal/SVP layer (2D) | Microscale | ↑ | 0.109 | 0.354 | 0.09* |
