Table 3 The 32 selected features and their changes (with P values) between healthy volunteers and patients with diabetes
Feature number | Feature description | Feature scale | Feature change | P values |
|---|---|---|---|---|
1 | Number of vessels in the epidermal/SVP layer (2D) | Mesoscale | ↓ | <0.001*** |
2 | Number of junctions in the epidermal/SVP layer (2D) | Mesoscale | ↓ | <0.001** |
3 | Number of junction-to-junction branches in the dermal layer (2D) | Mesoscale | ↓ | 0.011* |
4 | Number of junction-to-junction branches in the epidermal/SVP layer (2D) | Mesoscale | ↓ | 0.001*** |
5 | Thickness of the dermal layer (3D) | Macroscale | ↑ | 0.174 |
6 | Total area of vessels in the dermal layer (3D) | Macroscale | ↑ | 0.165 |
7 | Area of the dermal layer (2D) | Macroscale | ↑ | 0.126 |
8 | Average vessel length in the dermal layer (2D) | Microscale | ↓ | 0.031* |
9 | Number of junction-to-endpoint branches in the epidermal/SVP layer (2D) | Mesoscale | ↓ | <0.001*** |
10 | Number of junction-to-endpoint branches in the epidermal/SVP layer (3D) | Mesoscale | ↑ | 0.387 |
11 | Number of vessels in the epidermal/SVP layer (3D) | Mesoscale | ↑ | 0.690 |
12 | Thickness of the epidermal/SVP layer (3D) | Macroscale | ↑ | 0.170 |
13 | Number of vessels in the dermal layer (3D) | Mesoscale | ↓ | 0.093 |
14 | Total area of vessels in the epidermal/SVP layer (3D) | Macroscale | ↑ | 0.153 |
15 | Area of the dermal layer (3D) | Macroscale | ↓ | 0.546 |
16 | Number of junctions in the epidermal/SVP layer (3D) | Mesoscale | ↑ | 0.719 |
17 | Average vessel area in the dermal layer (2D) | Microscale | ↑ | 0.904 |
18 | Number of junction-to-junction branches in the epidermal/SVP layer (3D) | Mesoscale | ↑ | 0.737 |
19 | Total area of vessels in the dermal layer (2D) | Macroscale | ↑ | 0.993 |
20 | Number of junctions in the dermal layer (3D) | Mesoscale | ↓ | 0.084 |
21 | Number of junction-to-junction branches in the dermal layer (3D) | Mesoscale | ↓ | 0.084 |
22 | Total area of vessels in the epidermal/SVP layer (2D) | Macroscale | ↓ | 0.159 |
23 | Area of the epidermal/SVP layer (3D) | Macroscale | ↑ | 0.972 |
24 | Average vessel volume in the dermal layer (3D) | Microscale | ↑ | 0.010* |
25 | Average vessel area in the epidermal/SVP layer (2D) | Microscale | ↑ | 0.595 |
26 | Area of the epidermal/SVP layer (2D) | Macroscale | ↓ | 0.181 |
27 | Number of junction-to-endpoint branches in the dermal layer (3D) | Mesoscale | ↓ | 0.279 |
28 | Thickness of the dermal layer (2D) | Macroscale | ↑ | 0.374 |
29 | Thickness of the epidermal/SVP layer (2D) | Macroscale | ↓ | 0.161 |
30 | Average vessel volume in the epidermal/SVP layer (3D) | Microscale | ↑ | 0.138 |
31 | Average vessel diameter in the dermal layer (3D) | Microscale | ↑ | 0.035* |
32 | Average vessel diameter in the epidermal/SVP layer (3D) | Microscale | ↑ | 0.094 |
