Extended Data Fig. 4: HMEJ-engineered and lentivirally transduced CD19 CAR T cells produce cytokines in response to target cells, as measured by ICS. | Nature Biomedical Engineering

Extended Data Fig. 4: HMEJ-engineered and lentivirally transduced CD19 CAR T cells produce cytokines in response to target cells, as measured by ICS.

From: Cas9-induced targeted integration of large DNA payloads in primary human T cells via homology-mediated end-joining DNA repair

Extended Data Fig. 4: HMEJ-engineered and lentivirally transduced CD19 CAR T cells produce cytokines in response to target cells, as measured by ICS.

Percentage of cells expressing cytokines IFNγ, TNF, and IL2 as well as a degranulation marker CD107a in CD4 (left panels) and CD8 (right panels) CD19 CAR T cells following coculture with CD19+ Raji target cells.

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