Extended Data Fig. 1: B-cell-editing approaches.
From: In vivo affinity maturation of mouse B cells reprogrammed to express human antibodies
The human or mouse heavy-chain and kappa light-chain loci are represented, with HDRT shown underneath each chromosomal target. Scissors indicate a double-strand break introduced by the Cas9 CRISPR effector protein, or Mb2Cas12a. References for each editing approach are indicated beneath each panel12,13,14,15,16,18,60,61,62,63.
