Extended Data Fig. 8: GRHL3 or RNF114 expression is negatively correlated to both CD8+ T cell infiltration and overall survival in patients with multiple cancers.
From: PIEZO1 mechanically regulates the antitumour cytotoxicity of T lymphocytes
a, Highly expressed GRHL3 shorten the overall survival (OS) in response to all immunotherapies in human cancers. b, c, Inverse correlation of the expression of GRHL3 with CD8+ T cells infiltration signature in patients with rectum adenocarcinoma (READ, n = 166), glioblastoma multiform (GBM, n = 153), lung squamous cell carcinoma (LUSC, n = 501) (b), skin cutaneous melanoma (SKCM-Primary, n = 471) and stomach adenocarcinoma (STAD, n = 415) (c). d, Correlation of a high RNF114 expression with comparatively poor prognosis for cancer patients in response to anti-CTLA4 therapy. e, Inverse correlation of the expression of RNF114 with CD8+ T cells infiltration signature in patients with stomach adenocarcinoma (STAD, n = 415), head and neck squamous cell carcinoma (HNSC, n = 522), prostate adenocarcinoma (PRAD, n = 498) and thymoma (THYM, n = 120). Log-rank test (a and d) or Pearson’s correlation test (b, c and e).
