Extended Data Fig. 7: BLUsH responses to repeated CTZ administration. | Nature Biomedical Engineering

Extended Data Fig. 7: BLUsH responses to repeated CTZ administration.

From: Imaging bioluminescence by detecting localized haemodynamic contrast from photosensitized vasculature

Extended Data Fig. 7

(a) Snapshots of the responses to three doses of CTZ infused over a luciferase-expressing cell pellet in a single animal, following the experimental paradigm of Fig. 3. CTZ was injected in 2.5-min epochs (blue shading at top), separated by 10 minute intertrial intervals. Timing with respect to infusion start is denoted at top. (b) Time courses of MRI signal change observed in ROIs defined around the cell pellet. Labeled traces denote CTZ injection trials 1, 2, and 3, and the infusion periods are denoted by blue shading. (c) Maps of mean response amplitude (5 min following CTZ start) and recovery amplitude (8 min after CTZ infusion end) averaged over the three CTZ infusion trials in an ROI around the luminescent xenograft.

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