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Hormonally mediated mechanical remodelling of human haematopoietic stem cells enhances their bone-marrow engraftment

Nature Biomedical Engineering volume 9, pages 604–605 (2025)Cite this article

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The success of haematopoietic stem and progenitor cell (HSPC) transplants, particularly those using cord blood, requires the cells’ engraftment to bone marrow. We discovered that the corticotropin-releasing hormone regulates the biomechanics and homing behaviour of HSPCs, enhancing bone-marrow engraftment through the mechanical remodelling of the cell’s cytoskeleton and the extracellular matrix.

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Fig. 1: CRH induces mechanical remodelling of human HSPCs.

References

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This is a summary of: Wu, M. et al. Enhanced engraftment of human haematopoietic stem cells via mechanical remodelling mediated by the corticotropin-releasing hormone. Nat. Biomed. Eng. https://doi.org/10.1038/s41551-024-01316-1 (2024).

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Hormonally mediated mechanical remodelling of human haematopoietic stem cells enhances their bone-marrow engraftment. Nat. Biomed. Eng 9, 604–605 (2025). https://doi.org/10.1038/s41551-024-01310-7

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