Extended Data Fig. 8: Inflammatory response of the gut-on-a-chip in different experimental conditions. | Nature Biomedical Engineering

Extended Data Fig. 8: Inflammatory response of the gut-on-a-chip in different experimental conditions.

From: A gut-on-a-chip incorporating human faecal samples and peristalsis predicts responses to immune checkpoint inhibitors for melanoma

Extended Data Fig. 8: Inflammatory response of the gut-on-a-chip in different experimental conditions.

A-D) Multiplex ELISA (Luminex) quantification in the epithelial (A) and endothelial (B) channels of the indicated cytokines in anaerobic conditions (C) or in comparison with healthy donors (D). Bars represent mean ± SD, two-tailed unpaired t test (A left p = 0.0379 for R vs NR and p = 0.011 for R Sup vs NR Sup), ordinary one-way ANOVA (A center p = 0.0227, A right p = 0.003, B p = 0.0001 for CTR vs NR Sup and p = 0.0026 for R Sup vs NR Sup, C p = 0.0006 for CTR vs R and p = 0.0009 for R vs NR, D center p = 0.0004 for CTR vs NR, p = 0.036 for R vs NR and p = 0.0187 for NR vs HD, D right p = 0.000062 for CTR vs NR, p = 0.00467 for R vs NR and p = 0.000478 for NR vs HD), Kruskal-Wallis test (D left p = 0.0069 for CTR vs R, p = 0.0004 for CTR vs HD and p = 0.0318 for NR vs HD).

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