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Vaccine design

Non-covalent assembly of multiple epitopes onto a single nanoparticle

An engineered nanobody enables modular display of multiple viral epitopes onto a single protein-based nanoparticle, leading to broad-spectrum immunization.

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Fig. 1: Designing a nanobody-mediated plug-and-play vaccine.
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Correspondence to Kim L. Good-Jacobson.

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Kealy, L.C., Good-Jacobson, K.L. Non-covalent assembly of multiple epitopes onto a single nanoparticle. Nat. Biomed. Eng (2025). https://doi.org/10.1038/s41551-025-01530-5

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