Extended Data Fig. 9: Human cell detection and biochemical analysis in reimplanted animals. | Nature Biomedical Engineering

Extended Data Fig. 9: Human cell detection and biochemical analysis in reimplanted animals.

From: Systematic production of human kidney organoids for transplantation in porcine kidneys during ex vivo machine perfusion

Extended Data Fig. 9: Human cell detection and biochemical analysis in reimplanted animals.The alternative text for this image may have been generated using AI.

a, Electrophoresed PCR products showing band sized 254bp for the detection of SRY (Y chromosome) in biopsy samples from organoid-infused kidneys before and after in vivo transplantation compared to the correspondent contralateral kidney biopsy samples. n= 3 NMP + org + 24h Tx (NMP #1, #2, #3 + org + 24h Tx) and n= 3 NMP + org + 48h Tx (NMP #4, #5, #6 + org + 48h Tx), and n= 1 NMP + org (NMP #0 + org) b, Blood and c, urine biochemical analysis performed in pigs before (t0, basal) and after reimplantation (Tx). n= 3 animals reimplanted with organoid-treated kidneys for 24h (NMP #1, #2, #3 + org + 24h Tx) and n= 3 animals reimplanted with organoid-treated kidneys for 48h (NMP #4, #5, #6 + org + 48h Tx). Kruskal-Wallis (two-sided) followed by Dunn’s multiple comparisons test. p values for statistically significant comparisons are shown.

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