Fig. 3: RNA expressions of sIVs and sEVs.
a, Small RNA abundance in sEVs and sIVs obtained from MSCs, 293T cells and HeLa cells (n = 3 biologically independent samples) b, Percentage of sRNA reads mapped to small non-coding RNA for sEVs and sIVs from MSCs, 293T cells and HeLa cells (miRNA, microRNA; snoRNA, small nucleolar RNA; snRNA, small nuclear RNA; tRNA, transfer RNA; rRNA, ribosomal RNA). c, Venn diagram for miRNAs identified in sIVs, sEVs and cells from MSCs, 293T cells and HeLa cells. d, PCA of miRNA datasets from MSCs, 293T cells and HeLa cells. e, Matchstick plot displaying the top 10 high-abundance miRNAs in sEVs and sIVs obtained from MSCs, 293T cells and HeLa cells. f, GO enrichment analysis of target genes for differentially expressed miRNAs between MSC-sIVs and MSC-sEVs. g, Target gene KEGG enrichment analysis for miRNAs that are differently expressed in MSC-sEVs and MSC-sIVs. Data are presented as mean ± s.e.m. Two-tailed unpaired Student’s t-test was used for the comparisons in a.
