Fig. 6: Inhibitory role of MSC-sIVs on ER stress in the retinas of light-damaged and rd10 mice. | Nature Biomedical Engineering

Fig. 6: Inhibitory role of MSC-sIVs on ER stress in the retinas of light-damaged and rd10 mice.

From: Small intracellular vesicles outperform small extracellular vesicles in uptake, drug delivery and retinal neuroprotection

Fig. 6

a, RNA sequencing of the retinas revealed pathway alterations between BL-PBS and BL-sIVs groups. b, RNA sequencing of the retinas revealed pathway alterations between rd10-PBS and rd10-sIVs groups. c, Heat map showing the score of typical intracellular pathways of total proteins in MSC-sIVs and MSC-sEV analysed using gene set variation analysis. d, Pathway enrichment analysis of target genes for differential miRNAs in the top 50 high-abundance miRNAs from MSC-sIVs and MSC-sEVs. e, Western blot analysis of ER stress-related proteins in the retinas of light-damaged mice. f,g, Western blot analysis of ER stress-related proteins in the retinas of rd10 mice at p21 (f) and p28 (g). Data in a–d were analysed using two-tailed unpaired Student’s t-test. Representative images are shown in e–g; similar results were obtained in at least 3 independent experiments.

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