Extended Data Fig. 7: Translocation junction profiles at on-target and predicted off-target sites following targeted KI at AAVS1 locus. | Nature Biomedical Engineering

Extended Data Fig. 7: Translocation junction profiles at on-target and predicted off-target sites following targeted KI at AAVS1 locus.

From: Non-viral targeted integration of large DNA in primary human T cells independent of double-stranded DNA breaks

Extended Data Fig. 7: Translocation junction profiles at on-target and predicted off-target sites following targeted KI at AAVS1 locus.The alternative text for this image may have been generated using AI.

a and b, Circos plots show the genome-wide translocations (orange lines) at two predicted off-target loci: chr6 OT1 (a) and chr19 OT2 (b), following HMEJ-, eePASSIGE-, PRIME-In 1.0-, and PRIME-In 2.0-mediated targeted KI. Colored lines connect the bait site to the prey site. Line colors (orange, from dark to light) indicates high to low hotspot enrichment, respectively.

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