Extended Data Fig. 1: Characterization of dominant rotor-containing macrocyclic peptides.
From: Illuminating the dark conformational space of macrocycles using dominant rotors
a, 2D Exchange spectroscopy of 11b (top) and 11c (bottom) in DMSO-d6 at 25 °C. The negative cross-peak in the spectrum of 11b suggests an exchange between two conformers on the NMR time scale due to atropisomerism at the biaryl rotor71,72. b, LC-MS chromatograms of linear starting material Fmoc-Trz-AGF (top), Ra-12c (middle) and Sa-12c (bottom) atropdiastereomeric macrocycles.
