Extended Data Fig. 2: Time-dependent enantiodivergent synthesis via Ir-catalyzed asymmetric allylic substitution with aniline. | Nature Chemistry

Extended Data Fig. 2: Time-dependent enantiodivergent synthesis via Ir-catalyzed asymmetric allylic substitution with aniline.

From: Time-dependent enantiodivergent synthesis via sequential kinetic resolution

Extended Data Fig. 2

a, Optimal results for the synthesis of both enantiomers of 9. b, The course of the e.e. value of 9 over the reaction time. Reaction conditions: aniline (0.2 mmol, 1.0 equiv.), (rac)-2a (2.0 equiv.), [Ir(cod)Cl]2 (1.5 mol%), (S)-L1 (6 mol%), 3,5-Cl2C6H3CO2H (10 mol%) in MeOH (0.1 M) at 40 °C.

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