Fig. 3: Scope of sulfilimines and synthetic application.
From: Bifunctional sulfilimines enable synthesis of multiple N-heterocycles from alkenes
Reaction conditions: alkene (0.2 mmol), sulfilimine (0.4 mmol), Bi(OTf)3 (0.4 mmol), [Ir(dFppy)3] (2 mol%) in DME (1 ml) at 10 °C under a 30 W blue LED. aMethyl methoxyacetate (1 ml) as solvent instead of DME, and base workup is not applied due to easier purification of these products in ionic form. Other types of N-heterocycles, including oxazepanes, piperazines, dihydrooxazoles, dihydroimidazopyridiniums and dihydroimidazotriazinones, are accessible with the modular cyclization approach. A concise route to H1 receptor antagonist 41 has been developed based on the cyclization method.
