Fig. 5: Adaptive insertion for programmable surface functionalization.
a–c, Substitution of molecular probes loaded onto polymersomes. a, Loaded Na-PEG4-Os was released into solution after the addition of Py-PEG4-Im for 0 or 10 min and the absorbance at various wavelengths was measured. The right-hand y-axis represents absorbance (a.u.). The dotted line is the absorbance of the loaded Na-PEG4-Os. b, Substitution of Na-PEG4-Os or Py-PEG4-Os loaded onto polymersomes by adding Py-PEG4-Im or water. Each value corresponds to a mean of n = 2 replicates. c, Schematic of the substitution of molecular probes loaded onto polymersomes. d–f, On/off insertion switch by alternately adding PSS and CaCl2. d, De-insertion of loaded Py-PEG4-Os by adding PSS, PEG, PAA or Na2SO4. The data are presented as means ± s.d. of n = 3 independent experiments. e, Re-insertion of Py-PEG4-Os by adding CaCl2 or NaCl. Each value corresponds to a mean of n = 2 replicates. f, Schematic of the on/off insertion switch.
