Fig. 1: Previous work, reaction design and optimisation.
From: Catalytic enantioselective nucleophilic desymmetrization of phosphonate esters
a, State-of-the-art in catalytic enantioselective desymmetrization of P(V) compounds. b, A two-phase strategy for the construction of diverse enantioenriched P(V) compounds consisting of a bifunctional iminophosphorane-catalysed enantioselective nucleophilic substitution and downstream enantiospecific modification of the resulting enantioenriched intermediate. c, Effect of the nature of the leaving group on reaction efficiency and selectivity (left) with representative unsuccessful catalyst classes (right). CuAAC, copper-catalysed azide–alkyne cycloaddition; PdAAA, palladium-catalysed asymmetric allylic alkylation; LG, leaving group; Nu, nucleophile; r. t., room temperature; PT, phase transfer.
