Table 2 Derivatization of the desymmetrized enantioenriched P(V) products

From: Catalytic enantioselective nucleophilic desymmetrization of phosphonate esters

  1. P−O bond formation, P−S and P−N bond formation and synthesis of a cycloSal prodrug derivative. a tBuMgCl (3 equiv.) was used. b tBuMgCl (4 equiv.) was used. DBU, 1,8-diazabicyclo(5.4.0)undec-7-ene; TBS, tert-butyldimethylsilyl; TFA, trifluoroacetic acid; Bn, benzyl; Boc, tert-butyloxycarbonyl; r.t., room temperature.
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