Extended Data Fig. 7: Scatter plots of the three geometric measurements used to evaluate conformational fluctuations.

a, fluctuations of aminobenzoic acids 2–4 and b, fluctuations of cyclic β2,3-amino acid 2-aminocyclopentane-1-carboxylic acid monomers 5–8 in comparison to Met 1 in the PTC of the RRM throughout the MD runs are shown. Specifically, the Nα–Csp2 distance is plotted against either the Bürgi–Dunitz angle αBD (left) or the Flippin-Lodge angle αFL (center), and the two angles are plotted against each other (right). The gray zones highlight Nα – Csp2 distances of between 3 and 4 Å, and values of αBD and αFL of between 90° and 105° and 5° to 20°, respectively.