Extended Data Fig. 3: Additional control experiments.
From: Hydrogenative alkene perdeuteration aided by a transient cooperative ligand
a,b, Deuteration attempts in the absence of H2 (see Supplementary Fig. 97); the incomplete deuteration in D-1a may be due to consumption of the ruthenium-hydride complex without regeneration. c,d, Deuterogenation with D2 in a 30 mL (c) and 220 mL (d) reactor; the improvement in the deuterium content of D-2a indicates that the reaction is affected by the amount of D2, which can be explained by the theoretical D content of the system (considering 1.5 mmol of H atoms in 1a; see Supplementary Note 3). e, Deuterogenation with D2 in a 220 mL reactor in the absence of thiol; the results indicate direct exchange between D2 and Ru-1. f, Hydrogenative perdeuteration of 1a; although only 0.6 mmol of H2 was employed, the thiol ensured fast and continuous transfer of deuterium from D2O (55 mmol) to both H2 and the alkene C − H bonds.
