Stereoselective decarboxylative protonation can produce diverse chiral molecules from widely available carboxylic acids. However, general and practical strategies are lacking. Now, a chiral spirocyclic phosphoric acid-catalysed decarboxylation of aminomalonic acids has enabled the modular synthesis of α-amino acids.
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Lin, X., Woldegiorgis, A.G. An acid for an acid. Nat. Chem. 15, 1655–1656 (2023). https://doi.org/10.1038/s41557-023-01370-3
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DOI: https://doi.org/10.1038/s41557-023-01370-3
