Fig. 2: Synthesis of [2]rotaxane building blocks 6·Ma and 6·Mb. | Nature Chemistry

Fig. 2: Synthesis of [2]rotaxane building blocks 6·Ma and 6·Mb.

From: Masked alkynes for synthesis of threaded carbon chains

Fig. 2: Synthesis of [2]rotaxane building blocks 6·Ma and 6·Mb.The alternative text for this image may have been generated using AI.

Active metal template coupling of terminal butadiyne 1 and bromoalkyne 2 in the presence of macrocycle Ma or Mb was used to synthesize rotaxanes 3·Ma and 3·Mb, which were then converted into 6·Ma and 6·Mb. Asterisk indicates yield over two steps.

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