Fig. 4: Use of RuAqua 3 as a platform precatalyst for discovery.
From: An air- and moisture-stable ruthenium precatalyst for diverse reactivity
a–d, Discovery platform for reduction reactions using 3 as the precatalyst. a, Selection of unsaturated compounds explored. b, Reaction set-up: reactions were conducted neat and at ambient temperature (19 °C) for 24 h. c, Results: conversion percentages of starting materials were determined by 1H NMR spectroscopy using an internal standard. d, Reactions were validated for select entries for both silane and borane reductants. e–h, High-throughput experimentation (HTE) photocatalyst selection by in situ formation of Ru(bpy)32+ analogues applied to the XAT radical 1,4-addition. e, Ligands examined during screening. f, Reaction set-up: 3 premixed with L1–L15 in CH3CN/CH2Cl2 and irradiated for 1 h; 47, 48 and NEt3 (2.0 equiv.) were then added, and the mixture was further irradiated for 18 h. g, Results: reaction yields were determined by gas chromatography with flame ionization detection using an internal standard. h, Photocatalyst 40 (from L13) was isolated and used directly in the reaction and compared to [Ru(bpy)3](BF4)2.
