Extended Data Fig. 1: The hidden sequence space of αKG-HExxH family in Nature. | Nature Chemistry

Extended Data Fig. 1: The hidden sequence space of αKG-HExxH family in Nature.

From: Fused radical SAM and αKG-HExxH domain proteins contain a distinct structural fold and catalyse cyclophane formation and β-hydroxylation

Extended Data Fig. 1

a, Summary of the protein families that are fused to αKG-HExxH family protein, including standalone αKG-HExxH proteins, and αKG-HExxH proteins that are fused with an rSAM, tetratricopeptide repeat (TPR) or other protein families. b, Unrooted maximum-likelihood phylogenetic tree of the αKG-HExxH domains excised from their native protein sequence. The phylum information and the presence (+) or absence (−) of the HExxH and PWRxxxRP motif are annotated on the tree.

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