Much natural-product-based drug discovery has depended on the practices of Indigenous Peoples, who have sometimes invested centuries of care into the cultivation and use of plant or fungal matter. However, the contributions of the original discoverers can be lost as the natural products are developed into pharmaceutical products.
This is a preview of subscription content, access via your institution
Relevant articles
Open Access articles citing this article.
-
The translational potential of salvinorin A: systematic review and meta-analysis of preclinical studies
Translational Psychiatry Open Access 10 October 2025
Access options
Access Nature and 54 other Nature Portfolio journals
Get Nature+, our best-value online-access subscription
$32.99 / 30 days
cancel any time
Subscribe to this journal
Receive 12 print issues and online access
$259.00 per year
only $21.58 per issue
Buy this article
- Purchase on SpringerLink
- Instant access to the full article PDF.
USD 39.95
Prices may be subject to local taxes which are calculated during checkout
References
Ortega, A., Blount, J. F. & Manchand, P. S. J. Chem. Soc. Perkin Trans. 1, 2505–2508 (1982).
Roth, B. L. et al. Proc. Natl Acad. Sci. USA 99, 11934–11939 (2002).
Roach, J. J. & Shenvi, R. A. Bioorg. Med. Chem. Lett. 28, 1436–1445 (2018).
Valdés, L. J. III, Díaz, J. L. & Paul, A. G. J. Ethnopharmacol 7, 287–312 (1983).
Johnson, J. B. The Elements of Mazatec Witchcraft (University of California, 1938).
Maqueda, A. E. in Plant Medicines, Healing and Psychedelic Science: Cultural Perspectives (eds Labate, B. C. & Cavnar, C.) 55–70 (Springer, 2018).
Wasson, R. G. Botanical Museum Leaflets, Harvard University 20, 77–84 (1962).
Jenks, A. A., Walker, J. B. & Kim, S. C. J. Plant Res. 124, 593–600 (2011).
Triplett, E. W. Plant and Soil 186, 29–38 (1996).
Van Deynze, A. et al. PLOS Biol. 16, e2006352 (2018).
Carroll, S. R., Rodriguez-Lonebear, D. & Martinez, A. Data Sci. J. 18, 31 (2019).
Claw, K. G. et al. Nat. Commun. 9, 2957 (2018).
Gerber, K. et al. ACS Pharmacol. Transl. Sci. 4, 573–577 (2021).
Hudson, M. et al. Nat. Rev. Genet. 21, 377–384 (2020).
Author information
Authors and Affiliations
Corresponding authors
Ethics declarations
Competing interests
R.A.S has filed a patent on modifications to salvinorin A: WO2018231618. K.J.C. has no competing interests.
Rights and permissions
About this article
Cite this article
Clay, K.J., Shenvi, R.A. The original caretakers of salvinorin A and recognizing Indigenous contributions to science. Nat. Chem. 16, 1735–1736 (2024). https://doi.org/10.1038/s41557-024-01659-x
Published:
Version of record:
Issue date:
DOI: https://doi.org/10.1038/s41557-024-01659-x
This article is cited by
-
The translational potential of salvinorin A: systematic review and meta-analysis of preclinical studies
Translational Psychiatry (2025)
