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Synthetic methodology

Accelerating stereoselective radical cross-couplings

Aminoalcohols are vital motifs in chemical synthesis; however, traditional synthetic technologies relying on polar disconnections have various limitations. Now, such motifs can be expediently accessed by leveraging a radical-based approach, enabling the stereoselective preparation of an array of valuable building blocks.

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Fig. 1: Synthetic technologies for accessing vicinal aminoalcohols.

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Correspondence to Markus D. Kärkäs.

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Alvey, G.R., Avetian, D.L. & Kärkäs, M.D. Accelerating stereoselective radical cross-couplings. Nat. Chem. 17, 8–10 (2025). https://doi.org/10.1038/s41557-024-01702-x

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