Skip to main content

Thank you for visiting nature.com. You are using a browser version with limited support for CSS. To obtain the best experience, we recommend you use a more up to date browser (or turn off compatibility mode in Internet Explorer). In the meantime, to ensure continued support, we are displaying the site without styles and JavaScript.

  • News & Views
  • Published:

Off-target drug interactions

Secret action of gastric acid controlling drug

Nature Chemistry volume 17, pages 468–470 (2025)Cite this article

Subjects

Proton pump inhibitors, commonly prescribed for excessive gastric acid secretion, may lead to unexpected side effects. Now a chemoproteomic method enables a comprehensive profiling of their off-target interactions, offering valuable insights into their mechanism of action in living cells.

This is a preview of subscription content, access via your institution

Access options

Rent or buy this article

Prices vary by article type

from$1.95

to$39.95

Learn more

Prices may be subject to local taxes which are calculated during checkout

Fig. 1: Reactivity-based protein profiling of rabeprazole uncovers potential off-target.

References

  1. World Health Organization Model List of Essential Medicines: 22nd List 62 (World Health Organization, 2021).

  2. Sachs, G., Shin, J. M. & Howden, C. W. Aliment. Pharmacol. Ther. 23, 2–8 (2006).

    CAS  PubMed  Google Scholar 

  3. Castellana, C. et al. Pol Arch Intern Med 131, 541–549 (2021).

    PubMed  Google Scholar 

  4. Haastrup, P. F., Thompson, W., Søndergaard, J. & Jarbøl, D. E. Basic Clin. Pharmacol. Toxicol. 123, 114–121 (2018).

    CAS  PubMed  Google Scholar 

  5. Chinzon, D., Domingues, G., Tosetto, N. & Perrotti, M. Arq. Gastroenterol. 59, 219–225 (2022).

    PubMed  Google Scholar 

  6. Marker, T. et al. Nat. Chem. https://doi.org/10.1038/s41557-025-01745-8 (2025).

    Article  PubMed  Google Scholar 

  7. Shin, J. M., Cho, Y. M. & Sachs, G. J. Am. Chem. Soc. 126, 7800–7811 (2004).

    CAS  PubMed  Google Scholar 

  8. van Geel, R., Pruijn, G. J. M., van Delft, F. L. & Boelens, W. C. Bioconjugate Chem 23, 392–398 (2012).

    Google Scholar 

  9. Strand, D. S., Kim, D. & Peura, D. A. Gut and Liver 11, 27–37 (2017).

    CAS  PubMed  Google Scholar 

  10. Huber, M. A. et al. Pancreas 51, 1118–1127 (2022).

    CAS  PubMed  PubMed Central  Google Scholar 

Download references

Author information

Authors and Affiliations

  1. Synthetic and Functional Biomolecules Center, Beijing National Laboratory for Molecular Sciences, Key Laboratory of Bioorganic Chemistry and Molecular Engineering of Ministry of Education, College of Chemistry and Molecular Engineering, Peking University, Beijing, China

    Linghao Kong & Chu Wang

  2. Peking-Tsinghua Center for Life Sciences, Academy for Advanced Interdisciplinary Studies, Peking University, Beijing, China

    Linghao Kong & Chu Wang

Authors
  1. Linghao Kong
    View author publications

    Search author on:PubMed Google Scholar

  2. Chu Wang
    View author publications

    Search author on:PubMed Google Scholar

Corresponding authors

Correspondence to Linghao Kong or Chu Wang.

Ethics declarations

Competing interests

The authors declare no competing interests.

Rights and permissions

Reprints and permissions

About this article

Check for updates. Verify currency and authenticity via CrossMark

Cite this article

Kong, L., Wang, C. Secret action of gastric acid controlling drug. Nat. Chem. 17, 468–470 (2025). https://doi.org/10.1038/s41557-025-01788-x

Download citation

  • Published:

  • Version of record:

  • Issue date:

  • DOI: https://doi.org/10.1038/s41557-025-01788-x

Search

Advanced search

Quick links

Nature Briefing: Translational Research

Sign up for the Nature Briefing: Translational Research newsletter — top stories in biotechnology, drug discovery and pharma.

Get what matters in translational research, free to your inbox weekly. Sign up for Nature Briefing: Translational Research