G-protein-coupled receptors (GPCRs) are linked to a plethora of human diseases, but the efficacy of drugs that target GPCRs often varies between patients. Now, a link has been established between the gut microbiome and GPCR drug metabolism, in which the identities of the microbes directly influence the metabolites formed and the host drug response.
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Bracken, A.K., Chang, P.V. Gut microbiota-mediated GPCR drug metabolism affects downstream pharmacological activity. Nat. Chem. 17, 781–783 (2025). https://doi.org/10.1038/s41557-025-01840-w
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DOI: https://doi.org/10.1038/s41557-025-01840-w
